Wednesday 6 April 2016

Destroying human embryos for research

The latest biannual report to Parliament from the National Health and Medical Research Council Embryo Research Licensing Committee was tabled on 30 March 2016. It covers the six month period to 31 August 2015.

So-called "excess" human embryos

Commonwealth legislation establishing a national licensing scheme for research involving so-called “excess ART [artificial reproductive technology] embryos” was passed in 2003, with all States and Territories subsequently passing complementary legislation. “Excess ART embryos” are human embryos initially created by the fertilisation of a human egg with a human sperm in a laboratory with the intention of implanting the human embryo in the body of a woman with the hope that it would develop through to live birth.

The routine practice of artificial reproductive technology in Australia involves:
  • the chemical stimulation of the woman’s ovaries to produce several eggs at once; 
  • the fertilisation of all these eggs by human sperm;
  • the implanting of no more than two of the resulting human embryos into the woman’s body, and
  • the freezing of all the remaining human embryos. 
The frozen human embryos may be subsequently thawed and implanted in subsequent attempts at gestating a human embryo through to live birth.

However, not all frozen human embryos get used before a woman decides to abandon further attempts at gestating live born babies, either because:
  • an earlier attempt is successful and she doesn’t want any more live born children;
  • a relationship ends; 
  • she dies or becomes too ill to attempt pregnancy; or 
  • the process of ART becomes simply too stressful.


Growing stockpile of human embryos

As a consequence the stockpile of human embryos in frozen storage continues to grow from year to year. In Western Australia alone there were 20,323 human embryos in frozen storage as at 30 June 2015, up 955 (4.7%) from 30 June 2014.

Those who believe the human embryo has no inherent value naturally see this vast stockpile as a source of raw research material.

Additionally, human embryos fertilised in the laboratory for ART are subject to various tests to identify those which are considered unsuitable or undesirable for implanting in a woman’s body. This includes those considered to have a lower chance of developing to live birth as well as those identified on eugenic grounds as having, or more likely to have, an undesirable characteristic, a genetic or chromosomal disability.


1279 "excess" human embryos destroyed for research 

Since 2003 a total of 1,279 so-called "excess" human embryos have been used and destroyed in Australia under a total of 14 licenses under the national scheme.

Of these 725 human embryos were used to create a total of 80 human embryonic stem cell lines. While the public and parliamentary debate in 2003 centred around a claim that human embryonic stem cells would be used to directly cure a range of diseases and injuries including diabetes, spinal injury and Parkinson’s disease in reality as the most recent report indicates these human embryonic stem cell lines are used for “basic disease research and drug development projects”. (There has never been a clinical trial using human embryonic stem cells in Australia and only five such trials in the United States, with one cancelled part way through and the other four still under way and yet to publish any results. All four trials under way are only testing safety not efficacy at this point.)

Of the other 554 so-called “excess” human embryos destroyed in licensed research, 149 were used in looking for new search and destroy methods to test other human embryos to identify those that were undesirable for “use” in an ART procedure. The remaining 405 were used in refining the manufacturing processes used in ART, including 259 human embryos used in testing a new freezing device.


Human cloning for destructive research

In 2007 the Commonwealth legislation was amended to permit, under license, the deliberate creation of a human embryo in the laboratory for the purpose of research. Under the new legislation, human embryos could be created by three ways: 

  • somatic cell nuclear transfer (SCNT) , which involves removing the nucleus of a human egg and replacing it with a nucleus from another human cell; 
  • parthenogenesis, which involves activating a unfertilised human egg to develop in the same way as a fertilised egg; or 
  • fertilising a human egg obtained from an aborted baby girl with human sperm.

No one has attempted the third horrific approach but it remains lawful in Australia, except in Western Australia where legislation to allow these three forms of creating human embryos for destructive research was defeated in the Legislative Council.

Since 2007 a total of five licenses have been issued to permit the creation of human embryos for destructive research, three using SCNT and two using parthenogenesis.

A total of 104 human embryos have been manufactured under these licenses using 683 human eggs. None of these human embryos were cultivated past the 32 cell compact morula stage so no human embryonic stem cells have been obtained in this way. The final licenses that permitted the creation of human embryos expired on 16 December 2015. So after an eight year experiment and the deliberate creation and destruction of 104 little human beings there is nothing to show.


Death of the innocent as the way to utopia?

Adding the two categories together the death toll from the 2003 and 2007 legislation stands at 1,383. However the seven current licenses already provide for up to 1,902 more “excess” human embryos to be destroyed.

Each one of us was a human embryo once. 

James L. Sherley, a stem cell biologist and Harvard graduate commenting on Harvard University’s push to be involved in human cloning wrote:

A defining feature of our humanity is that we also have the capacity to do the same for others whom we do not know. If the hands of members of the Harvard review board were sensitive enough, they could come to know human embryos better. They could feel that the smallest such embryos, like us, are warm to the touch, that they move as they grow, and they breathe just as surely as we do. (Boston Globe, 12 June 2006)

The willingness to destroy human embryos – the littlest of us – in pursuit of research into more efficient baby making; cures for diseases and more efficient eugenics is a sign of a society that has failed the fundamental test posed by Dostoevsky’s Ivan Karamazov to his brother Alyosha:

Tell me yourself, I challenge you—answer. Imagine that you are creating a fabric of human destiny with the object of making men happy in the end, giving them peace and rest at last, but that it was essential and inevitable to torture to death only one tiny creature—that baby beating its breast with its fist, for instance—and to found that edifice on its unavenged tears, would you consent to be the architect on those conditions? Tell me, and tell the truth. (Brothers Karamazov, page 269)


Australian parliaments have tragically passed laws pretending to bring us closer to utopia at the cost of taking the lives of several thousand human embryos. Like Alyosha Karamazov we must reject the idea that those “for whom you are building it would agree to accept their happiness on the foundation of the unexpiated blood of a little victim … and accepting it would remain happy for ever”.


All those who seek to defend human life should work for the repeal of the 2003 and 2007 legislation insofar as it permits the destruction of even a single one of the littlest ones of us.